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CAPture
October 3, 2007 |


CAPture is a commentary on recent allergy papers related to the product areas of Phadia. CAPture is issued six times a year.

 

 


 

2008
 
 
  • IgE antibodies to ovomucoid showed superior diagnostic performance in diagnosing clinical allergy to heated egg in children.
     
  • Most peanut-allergic children with first reaction at an age above 2 years showed a decrease in peanut-specific IgE antibodies within 3 years.
     
  • High grass-specific IgE levels are associated with more severe rhinitis in children during pollen season and also better outcome from anti-IgE therapy.
 
  • High levels of IgE antibodies to peanut and and walnut predict symptomatic food allergy and decrease the need of challenge tests.
     
  • Cat allergic children with asthma have higher concentration of IgE antibodies to the cat allergen component rFel d 1 than children with rhinitis.
     
  • Moderate concentrations of IgE antibodies to wheat or rye are good predictors for a positive inhalation challenge test in bakers.
 
  • Published predictive values for clinical reactivity associated with foodspecific IgE levels determined by ImmunoCAP® should not be applied to results from other systems.
     
  • Quantitative measurements of serum IgE antibodies to milk, egg and fish are useful to evaluate food-allergy in preschool children.
     
  • The serum concentration of IgE antibodies to egg is associated with the severity of reaction after food challenge in childhood egg allergy.
 
  • IgE antibodies to hazelnut nsLTP (Cor a 8) are common and associated with more severe symptoms in children from birch-endemic region of Northern Europe.
     
  • Every second infant with moderate/severe atopic eczema with onset before six months of age has a high risk for clinical relevant food sensitization.
     
  • Skin prick testing, using a cut-off at >0 mm, only detect 63.4-73.4% of subjects with a serum IgE >0.35 kUA/l to grass, mite and cat in a general population.
  • A new recombinant omega-5 gliadin peptide is more useful for IgE testing than other wheat allergens in diagnosing wheat-dependent, exerciseinduced anaphylaxis (WDEIA).
     
  • IgE antibodies to ImmunoCAP® fx5 are related to lower scores of Health Related Quality of Life in food-sensitized children with reported food hypersensitivity.
     
  • Non-Caucasian children in UK seem to have a higher risk of food allergy with the first reaction at earlier age, and to be sensitized to more food allergens.